|
KMID : 0616120200510020122
|
|
Korean Journal of Pharmacognosy
2020 Volume.51 No. 2 p.122 ~ p.130
|
|
|
Anti-inflammatory Effect of Herbal Complex HP-04 on Degenerative Osteoarthritis
|
|
Jo Hyoung-Kwon
Kim Dae-Sung
Kim Dae-Sung
Kim Jung-Young
Park Young-Mi
Shiin Dong-Yeop
Lee Hak-Yong
Kim Hoon
Lee Dong-Sung
Cho Seong-Wan
|
|
|
Abstract
|
|
|
|
To investigate the anti-inflammatory effect on Degenerative Osteoarthritis, Male sprague-Dawley rats were randomized and classified into three different concentration groups. We measured weekly weight change, dietary intake, drinking water intake, blood analysis like TNF-a (tumor necrosis factor-a), IL-6 (interleukin 6), TIMP-1 (tissue inhibitor of metalloprotease-1), MMP-2 (matrix metalloprotease-2), MMP-9 (matrix metalloprotease-9) and micro CT analysis. The results suggest that the treatment with herbal complex HP-04 improved the Monosodium iodoacetate (MIA) induced degenerative osteoarthritis and it could be applicable for the improvement of arthritic symptoms as a new therapeutic agent.
|
|
|
KEYWORD
|
|
|
Osteoarthritis, Monosodium iodoacetate, Herbal complex HP-04, TNF, IL-6, MMP-2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|